**Reference No** . R2812620 **Position Title:** Upstream Scientist Vaccines **Department** : DS Unit 1 NA **Duration:** Fixed Term Contract, 12 months **Location:** Toronto, ON **About the Job** We deliver 4.3 billion healthcare solutions to people every year, thanks to the flawless planning and meticulous eye for detail of our Manufacturing & Supply teams. With your talent and ambition, we can do even more to protect people from infectious diseases and bring hope to patients and their families. As Scientist, responsible for specific scientific, technical and compliance-related aspects of assigned projects to ensure that objectives are met. Plan and supervise the execution of development activities to ensure scientific excellence, adherence to advanced technical standards and compliance with GxP status of work. Fulfill the roles and responsibilities of a Scientist as defined by the Head of VDSD and Unit head. We are an innovative global healthcare company that helps the world stay ahead of infectious diseases by delivering more than 500 million vaccine doses a year. Across different countries, our talented teams are exploring new technologies to protect people and promote healthy communities. We chase the miracles of science every single day, pursuing progress to make a real impact on millions of patients around the world. **Main responsibilities:** + **Scientific:** Designs platform's experimental plan in support of projects. Prepares process development reports, scientific publications and external presentations. + **Contribution to Projects:** Working group member for responsible projects. + **Responsibilities:** Lead DKMs for responsible projects. + **Strategy and Impact:** Influence and implement departmental and company strategies within VCDS + **Influence:** Interact throughout VCDS **General** + As Scientist, L2-1, responsible for specific scientific, technical and compliance aspects of assigned project to ensure that objectives are met. Plan and supervise execution of process and product development activities (develop, improve, scale-up processes, and provide material and documentation supporting vaccine production for pre-clinical and clinical trials) within the Platform for the project to ensure scientific and technical excellence. + Supervise, train, motivate and empower technical personnel to perform the experimental and processing tasks. Ensure compliance of staff with GxP and other quality and documentation requirements, such as preparation of SOPs, BPRs and validation reports. Provide guidance on data input, standardized formats, database creation and management, and implementation of corporate standards. + To ensure good scientific and technical leadership within VDSD, keep abreast of the current developments in relevant scientific and technical disciplines and ensure current developments are implemented when appropriate. + Prepare internal and external presentations, research manuscripts and review articles as required. + Share information and harmonize development within VDSD, and other departments such as Research, Manufacturing Technology, Industrial Operations, Quality Operations, Regulatory Affairs, Clinical/Medical as necessary. Ensure good teamwork and provide high quality deliverables, such as Technical reports, development reports within agreed timeframes. Support regulatory submission by participating in preparation of regulatory submission documents (CTA, IND, CTD). + In depth knowledge of experimental work and data analysis. Working knowledge of computer skills, scientific writing and presentations, supervisory/management/people development, communication skills, innovative thinking, and a familiarity with strategic planning, balanced judgment, risk analysis and budget process is required. + Works with the policies, procedures and regulations as required by the Company and under Occupational Health and Safety Act. Ensure compliance with employment and health and safety legislation and ensure that employees follow the policies, procedures and regulations in the work areas. **Platform Specific** + Genetic engineering of microbial and cells and viruses for vaccine supply using molecular biology approaches, followed by preparation of pre-master seeds, cell lines and virus stocks and their characterization. + Development of media and nutrient feeds for the cultivation of microbes, animal cells and viruses for vaccine candidate supply. Development of process for GMP manufacturing of master and working cell bank and virus seeds. Development of scalable bioreactor process for GMP manufacturing of vaccine candidates including the selection of operating mode (batch, fed batch, continuous, biphasic, etc) and conditions for production scales of up to 200 L. Selection of scalable primary recovery approaches for bioreactor harvest concentration, cell disruption, and product recovery using combinations of filtration, centrifugation, homogenization, sonication, and chemical treatments. + Use of analytical methods for measuring cell densities, culture medium analysis, protein analysis, immunological detection of proteins (ELISA, Western blotting, etc), HPLC, virus titration by CCID or plaque assay, flow cytometry, and PCR. + Support for GMP manufacturing including process technology transfer, equipment selection and validation, process flows, vendor and raw materials selection, aseptic processing, and sterilization. + Application of biochemical engineering principles including mass and heat transfer, fluid dynamics, process control, process simulation and modelling, and equipment design. Use of advanced computer software to support bioreactor process control and data acquisition, DOE, process modelling and simulations, computational fluid dynamics, and experimental data analysis. **About You** **Requirements** **Education/experience** + Recommended PhD (Molecular Biology, Biochemistry, Microbiology, Virology, Biochemical Engineering) + Recommended 1+ years’ experience with a PhD or 4+ years’ experience with an MSc in vaccine development or relevant field. + Depending on development platform, in-depth knowledge in genetic engineering, upstream processes, downstream processes, formulation and stability. **Why Choose Us?** + Bring the miracles of science to life alongside a supportive, future-focused team. + Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. + Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. + Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs This position is for a current vacant role that we are actively hiring for.​ Sanofi is an equal opportunity employer committed to diversity and inclusion. Our goal is to attract, develop and retain highly talented employees from diverse backgrounds, allowing us to benefit from a wide variety of experiences and perspectives. We welcome and encourage applications from all qualified applicants. Accommodations for persons with disabilities required during the recruitment process are available upon request. \#GD-SP ​ \#LI-SP \#LI-Onsite **Pursue** **_progress_** **, discover** **_extraordinary_** Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) ! _North America Applicants Only_ The salary range for this position is: $76,200.00 - $110,066.66 All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through the LINK (https://myflex-benefits.ca/en/home/) . La fourchette salariale pour ce poste est la suivante: $76,200.00 - $110,066.66 Toute compensation sera déterminée en fonction de l'expérience démontrée. Les employés peuvent être admissibles à participer aux programmes d'avantages sociau de l'enterprise. Des informations supplémentaires sur les avantages sont disponibles via le lien (https://myflex-benefits.ca/fr/home/) . Global Terms & Conditions and Data Privacy Statement (https://www.sanofi.com/en/careers/global-terms-and-conditions/) Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visiting www.sanofi.com or via our movie We are Sanofi (https://youtu.be/96EwNjb1TLo) As an organization, we change the practice of medicine; reinvent the way we work; and enable people to be their best versions in career and life. We are constantly moving and growing, making sure our people grow with us. Our working environment helps us build a dynamic and inclusive workplace operating on trust and respect and allows employees to live the life they want to live. All in for Diversity, Equity and Inclusion at Sanofi - YouTube (http://www.youtube.com/watch?v=SkpDBZ-CJKw&t=2s)