**Job Title:** Senior Scientist, Ocular In Vivo Translational Sciences **Location:** Cambridge, MA **About the Job** Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. We are seeking a highly skilled Senior Scientist with expertise in in vivo ocular research to join Sanofi's innovative Ophthalmology Research team. You will contribute to IND-enabling preclinical studies, help develop novel disease models and support the advancement of innovative therapies for vision-threatening diseases. In this role, you will apply hands-on expertise in ocular techniques in close collaboration with internal and external teams and contribute to the development of preclinical ocular models and complex in vivo studies. **Main Responsibilities** + Execute and analyze in vivo ocular studies in relevant animal models to support drug discovery and development programs + Perform pharmacokinetics, pharmacodynamics, efficacy, and safety assessments of potential ocular therapeutics + Support the development and characterization of preclinical ocular disease models + Perform ocular dosing procedures, including intravitreal, intracameral, suprachoroidal, subretinal, topical, and systemic routes in rodents + Utilize advanced ocular imaging modalities (OCT, fundus photography, ERG, IOP, OKR) + Conduct molecular analyses including digital PCR, ELISA, and Western blotting + Perform histological techniques on tissue sections and flat mounts + Operate automated platforms for molecular and histological assays + Conduct ex vivo studies on ocular explants as needed + Author scientific publications and present research findings at internal governance meetings and external conferences + Manage ongoing and upcoming studies and collaborate with project team members to advance ophthalmology research programs + Familiarity with animal welfare regulations and ethical guidelines **About You** + Earned PhD in Vision Science, Ophthalmology, Pharmacology, Molecular Biology, or related field with 3+ years of relevant post-PhD/doc experience in an academic or biopharmaceutical setting + Demonstrated experience in designing, executing, and interpreting in vivo ocular studies with hands-on expertise in ocular disease models + Advanced proficiency in surgical and non-surgical techniques for ocular research in rodent models, including various routes of ocular drug administration + Strong knowledge of ocular anatomy, physiology, and pathology with expertise in using ocular imaging modalities (OCT, fundus photography, ERG, IOP, OKR) + Proficiency in molecular biology and histological techniques + Track record of scientific publications in peer-reviewed journals related to ocular research + Strong data analysis, interpretation skills, and experience with documentation for regulatory submissions + Excellent project management and communication skills with flexibility to pivot to meet changing project needs and deadlines **Preferred qualifications** + Hands-on experience phenotyping ocular disease models in AMD, glaucoma, DME, DR, etc. + Experience conducting PK, PD and efficacy studies in ocular models + Experience with automated methodologies for tissue analysis such as automated nucleic acid and protein extraction from tissues and automated histology – IHC, IF, ISH. + Experience with therapeutic modalities including small molecules, biologics, proteins, nucleic acids, and gene therapies + Experience conducting and managing animal (small and large) studies at contract research organizations + Experience analyzing data using computational approaches **Skills and competencies:** + Advanced in vivo expertise and deep scientific knowledge in the ocular field + Ability to take the lead on research initiatives + Training capabilities to guide junior team members and troubleshoot complex issues + Innovation mindset with focus on developing novel approaches and pushing scientific boundaries + Cross-functional collaboration skills to work effectively across teams and key stakeholders **Why Choose Us** + Bring the miracles of science to life alongside a supportive, future-focused team. + Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. + Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. + Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. \#GD-SA \#LI-SA \#LI-Onsite \#vhd **Pursue** **_progress_** **, discover** **_extraordinary_** Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) ! _US and Puerto Rico Residents Only_ Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally inclusive and diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; natural or protective hairstyles; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. _North America Applicants Only_ The salary range for this position is: $100,500.00 - $145,166.66 All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through the LINK (https://benefits.sanofiusallwell.com/fleet/public/index/ba511bf8-5c32-4828-9861-ab985fffab90/?cid=sanofi) . Global Terms & Conditions and Data Privacy Statement (https://www.sanofi.com/en/careers/global-terms-and-conditions/) Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visiting www.sanofi.com or via our movie We are Sanofi (https://youtu.be/96EwNjb1TLo) As an organization, we change the practice of medicine; reinvent the way we work; and enable people to be their best versions in career and life. We are constantly moving and growing, making sure our people grow with us. Our working environment helps us build a dynamic and inclusive workplace operating on trust and respect and allows employees to live the life they want to live. All in for Diversity, Equity and Inclusion at Sanofi - YouTube (http://www.youtube.com/watch?v=SkpDBZ-CJKw&t=2s)