At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com **Job Function:** Discovery & Pre-Clinical/Clinical Development **Job Sub** **Function:** Biological Research **Job Category:** Scientific/Technology **All Job Posting Locations:** Cambridge, Massachusetts, United States of America, Spring House, Pennsylvania, United States of America **Job Description:** **About Innovative Medicine:** Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine **We are searching for the best talent for a** **Senior Principal Operational Scientist – Aging & Metabolism** **to be in Cambridge, MA or Spring House, PA.** **Purpose:** The Senior Principal Operational Scientist will provide scientific leadership and hands‑on support for translational research in thrombosis, sarcopenia, and cardiometabolic diseases, while also delivering key operational support. This hybrid role combines scientific responsibilities (in vivo and in vitro work) with operational functions, including project management, coordination of contracting, and administrative and laboratory support. The position requires integrating cardiopulmonary disease mechanisms, aging biology, and metabolic dysfunction while ensuring smooth execution across a cross‑functional research portfolio. **You will be responsible for** **:** **Scientific and Strategic (~50%)** + Lead and provide expertise in in vitro and in vivo studies supporting cardiometabolic and cardiopulmonary research. + Contribute to target identification, validation, and preclinical strategy development in areas such as HFpEF, Group 2 PH, vascular dysfunction, thrombosis, and age‑related muscle loss and weakness. + Partner with disease area leaders and project teams to develop mechanistic hypotheses and experimental plans aligned with Cardiopulmonary priorities. + Uphold strong scientific standards through rigorous data interpretation, clear internal communication, and contributions to publications and presentations. **Project Management, Coordination, and Administrative (~50%)** + Support project management for aging‑focused cardiopulmonary programs, ensuring clear milestones, timelines, and decision points. + Prepare and maintain project documentation, including development plans, data packages, governance materials, and decision‑support documents. + Organize and support internal and external meetings by preparing agendas, documenting outcomes, and ensuring timely follow‑up on action items. **Qualifications / Requirements:** **Education:** + Bachelor’s degree is required + Master’s degree or PhD is highly preferred **Required:** + Minimum of 8-10 years’ experience working in muscle biology, cardiovascular, and metabolism in the Pharmaceutical/Biotechnology industry (which can include education) + Strong scientific background in biology (e.g., aging, metabolism, cardiopulmonary, muscle biology) or in chemistry/biologics. + Experience contributing scientifically to drug discovery or translational programs in cardiometabolic, cardiovascular, or muscle‑related disease. + Demonstrated experience working in cross‑functional, matrixed research teams. + Strong written and verbal communication skills and the ability to manage multiple priorities effectively. + Travel up to 10% of the time (domestic and international), defined by business needs. The anticipated base pay range for this position in the US is $137,000 to $235,750. The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis. Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short and long-term disability, business accident insurance, and group legal insurance. Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). This position is eligible to participate in the Company’s long-term incentive program. Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits: + Vacation –120 hours per calendar year + Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year + Holiday pay, including Floating Holidays –13 days per calendar year + Work, Personal and Family Time - up to 40 hours per calendar year + Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child + Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year + Caregiver Leave – 80 hours in a 52-week rolling period 10 days + Volunteer Leave – 32 hours per calendar year + Military Spouse Time-Off – 80 hours per calendar year For additional general information on company benefits, please go to: https://www.careers.jnj.com/employee-benefits This job posting is anticipated to close on February 11, 2026. The Company may however extend this time-period, in which case the posting will remain available on https://www.careers.jnj.com to accept additional applications. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers , internal employees contact AskGS to be directed to your accommodation resource. \#LI-Hybrid **Required Skills:** **Preferred Skills:** **The anticipated base pay range for this position is :** $137,000.00 - $235,750.00 Additional Description for Pay Transparency: Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). This position is eligible to participate in the Company’s long-term incentive program. Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits: Vacation –120 hours per calendar year Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year Holiday pay, including Floating Holidays –13 days per calendar year Work, Personal and Family Time - up to 40 hours per calendar year Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year Caregiver Leave – 80 hours in a 52-week rolling period10 days Volunteer Leave – 32 hours per calendar year Military Spouse Time-Off – 80 hours per calendar year For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits