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The Bioanalytical Research Group (BAR) at Lilly’s research facility in South San Francisco, CA is seeking a strong scientist skilled in protein mass spectrometry to deliver innovative ways in our evaluation of the ADME properties of therapeutic proteins and antibody-drug-conjugates (ADCs). The team collaborates with Investigative ADME, Toxicology, Oncology, and Biotechnology Discovery Research to discover and characterize optimized ADC candidates to advance to clinical testing.

Primary Responsibilities:

The development and application of QQQ and high-resolution LC/MS approaches to characterize the PK, biotransformation, and bio-distribution of ADC drug candidates in pre-clinical animal models.The application of mass spectrometry and wet biochemistry to answer questions related to target engagement and ADC mechanism of action.This on-site role supports sample preparation, experimental develop and mass-spec analysis of biological samples as well as data analysis/interpretation from in-vivo studies from triple-quad and orbitrap mass spectrometers.Characterization of recombinant proteins, antibodies, and ADCs using intact-MS and peptide mapping for routine QC using high-resolution mass spec platforms (Oribtrap).

Job Requirements:

B.S. with 5+ years) in biochemistry/molecular biology, bioengineering, biology, pharmacology, chemistry, or scientific field Experience with mass spectrometry-based methods to support the bio-analysis of therapeutic proteins.Experience with a wide variety of sample preparation techniques including SPE, LLE, PPT, or immunoaffinity/hybridization techniques.

Additional Experience is Preferred:

Masters Degree. in biochemistry/molecular biology, bioengineering, biology, pharmacology, chemistry, or scientific subject area and 3+ years of significant work experience Knowledge of the operation and the routine maintenance of Thermo Orbitrap and Sciex QQQ mass spectrometers is preferredExcellent written and effective verbal communication.Strong work planning, record keeping and data analysis skills.Experience supporting ADC drug development, including assessing PK, Efficacy, and toxicology profiles in preclinical models and showcasing data to project teams is ideal.       Knowledge of the ADME principles of biotherapeutic drugs.Experience with proteomics methods, DDA, nano-LC, DIA, or similar workflows in a drug discovery setting.

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Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$65,250 - $193,600

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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