RESEARCH FELLOW **Extended Site Maintenance** We are performing updates and maintenance to our applicant experience. As a result, the site will be unavailable Saturday, January 24th at 8am EST through Sunday, January 25th at 7:30am EST. During this outage period, applications for job postings can not be submitted. Apply Now **Job Summary** This project will involve generating and testing brain-penetrant antibody-nucleic acid conjugates for reducing gene expression in the brain after intravenous administration. The goal is to prevent pathology in mouse models of neurodegenerative disease using a noninvasive, antibody-based technology. **Responsibilities*** The responsibilities will include cloning and producing bispecific antibodies, conjugating nucleic acids, and testing their pharmacokinetics and pharmacodynamics in vivo. In addition, the duties will also include testing the ability of the antibody-nucleic acid conjugates to prevent pathology in mouse models of neurodegenerative diseases. **Required Qualifications*** Molecular biology cloning of proteins and/or antibodies, protein expression and purification, and some animal handling experience. **Desired Qualifications*** Experience performing pharmacokinetic analysis of antibody or other protein therapeutics. **Modes of Work** Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about thework modes (https://hr.umich.edu/working-u-m/my-employment/ways-we-work-resource-center/ways-we-work-implementation-group/modes-work) . **Background Screening** The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks are performed in compliance with the Fair Credit Reporting Act. **U-M EEO Statement** The University of Michigan is an equal employment opportunity employer. **Job Detail** **Job Opening ID** 271435 **Working Title** RESEARCH FELLOW **Job Title** RESEARCH FELLOW **Work Location** Ann Arbor Campus Ann Arbor, MI **Modes of Work** Onsite **Full/Part Time** Full-Time **Regular/Temporary** Regular **FLSA Status** Exempt **Organizational Group** College Pharmacy **Department** PHARMACY Pharmaceutical Sci **Posting Begin/End Date** 12/01/2025 - 2/01/2026 **Career Interest** Research Fellows Apply Now