_Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l’international, l'anglais étant la langue de travail._ _This job offer is open to everyone, regardless of the gender the candidate identifies with._ **Job Title:** Process Development Laboratory Manager – New Modalities **Location:** Aramon, France **About the job** At Sanofi, we are pushing the boundaries of science to create the next generation of therapeutics. Within MSAT (Manufacturing Science & Technology) Synthetics organization, we are establishing a Chemistry Excellence Center dedicated to innovation in API process development and green chemistry. Our mission includes the advancement of innovative new molecules as well as new modalities such as synthetic RNA and novel excipients for cutting-edge drug delivery systems. We are building a high-performing, agile team that bridges early development and commercial manufacturing. If you are passionate about transforming innovation into reality, this is your opportunity to contribute at the heart of pharmaceutical development. As Laboratory Manager – New Modalities Development, you will lead a team working at the interface of traditional small-molecule chemistry and next-generation therapeutic platforms. You will support the design, optimization, and scale-up of synthetic routes and production processes – from lab bench to GMP batches – for novel nucleic acids and lipid-based excipients used in advanced therapies. This is a unique chance to play a strategic and hands-on role in shaping tomorrow’s medicines. **Main responsibilities** + Lead and mentor a team of Technical Engineers and/or Laboratory Technicians. + Oversee lab activities, ensuring high-quality, reproducible results and effective project execution. + Carry out scientific research / bibliography and proposing areas of work to resolve of technical or scientific issues. + Drive the development and scale-up of solid-phase synthesis processes for nucleic acids and assess sustainable solution as 2nd generation process. + Lead the development and support the industrialization of vaccine excipient like lipid used in lipid nanoparticle (LNP) formulations. + Participate in internal and external tech transfers, ensuring seamless knowledge flow and PPQ success. + Promote and apply green chemistry and risk-based approaches to develop safe and scalable processes. + Collaborate closely with internal stakeholders and external CDMOs throughout the development lifecycle. + Contribute to technical documentation, including reports and regulatory filings. + Stay informed on emerging technologies and contribute actively to innovation initiatives. + Organize laboratory operations efficiently: define work plans, manage schedules and team objectives, and support development plans (IDPs). + Promote a strong safety culture and compliance with HSE practices and behaviors. **About you** + **Education:** + MSc or PhD in Organic Chemistry, with a hands-on experience in nucleic acid chemistry + Minimum 5 years in the Pharmaceutical Industry, including successful experience in process development and industrialization. + **Technical Skills:** + Expertise in synthetic organic chemistry and solid-phase synthesis (e.g., oligonucleotides). + Experience in lipid and/or peptide synthesis is a strong plus. + Proficient in synthetic route scouting, kilo lab operations, and scale-up methodologies. + Solid understanding of GMP, process safety, and regulatory expectations for clinical manufacturing. + **Soft Skills:** + Strong scientific rigor, problem-solving ability, and proactive mindset. + Excellent collaboration and communication skills across multidisciplinary teams. + Curious, adaptive, goal-oriented and driven by innovation + **Languages:** + Fluency in French and professional proficiency in English. **Why choose us?** Take on a strategic and visible role that will accelerate the transition from lab-scale to clinical and commercial production. You will be working on transformative technologies in a dynamic, cross-functional environment. Ready to shape the future of therapeutics? **Pursue Progress. Discover Extraordinary.** Progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. You can be one of those people. Chasing change, embracing new ideas, and exploring all the opportunities we have to offer. Let’s pursue progress. And let’s discover extraordinary together. At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity. Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) ! **Pursue** **_progress_** **, discover** **_extraordinary_** Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) ! Global Terms & Conditions and Data Privacy Statement (https://www.sanofi.com/en/careers/global-terms-and-conditions/) Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visiting www.sanofi.com or via our movie We are Sanofi (https://youtu.be/96EwNjb1TLo) As an organization, we change the practice of medicine; reinvent the way we work; and enable people to be their best versions in career and life. We are constantly moving and growing, making sure our people grow with us. Our working environment helps us build a dynamic and inclusive workplace operating on trust and respect and allows employees to live the life they want to live. All in for Diversity, Equity and Inclusion at Sanofi - YouTube (http://www.youtube.com/watch?v=SkpDBZ-CJKw&t=2s)