At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. **The Position** **The Opportunity** Roche Sequencing Solutions (RSS) is defining a new class of Next-Generation Sequencing with our proprietary **Sequencing by Expansion (SBX)** technology. As a **Principal Scientist** in the **Reagent Bioinformatics** subchapter, you will help solve unprecedented computational challenges inherent in unexplored molecular workflows and sequencing applications. You can directly influence the trajectory of our state-of-the-art sequencing platform through internal and external collaborations. **Key Responsibilities** + Proactively investigate "first-in-kind" technical challenges in novel sequencing prep and applications on the new SBX platform. + Design and prototype computational tools for cutting-edge applications where standard pipelines may not apply. Be eager to delve into internal and third-party tools to understand their assumptions and limits. + Develop a deep understanding of the interplay between reagent chemistry and data quality to recommend iterative improvements for laboratory workflows and bioinformatics pipelines. + Collaborate closely with wet lab and computational scientists on experimental design, data analysis, QC, and visualization, ensuring high-quality results are communicated clearly across the team. **Qualifications** + Ph.D. in Bioinformatics, Computational Biology, or a related quantitative field. + In-depth knowledge of NGS, molecular biology, human genomics, and the "why" behind various sequencing modalities. + Expertise in diverse NGS applications including single cell, spatial transcriptomics, NGS based proteomics preferred. + Proficiency in Python and workflow managers (Nextflow or Snakemake) within distributed Linux environments, with experience producing well-documented, reproducible code. + Strong desire to solve unprecedented problems and a commitment to scientific rigor, ensuring routine QC and data tasks are completed with seamless precision. + Ability to thrive in multi-disciplinary teams and communicate technical findings to audiences of varying technical backgrounds **This is an onsite role in Pleasanton. Relocation benefits are not available.** The expected salary range for the Principal Scientist position based on the primary location of Santa Clara or Pleasanton is $121,400 - 225,400 Annual. Actual pay will be determined based on experience, qualifications and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance, as well as participation in a long-term incentive program. This position also qualifies for the benefits detailed at the link provided below. Benefits (http://roche.ehr.com/default.ashx?CLASSNAME=splash) Where pay transparency applies, details are provided based on the primary posting location. For this role, the primary location is Santa Clara. If you are interested in additional locations where the role may be available, we will provide the relevant compensation details later in the hiring process. **Who we are** A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact. Let’s build a healthier future, together. Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants (https://docs.google.com/forms/d/e/1FAIpQLSdZWlsbfQOvFVIQgHE\_iDzWUTlhZvj6FytIzjS7xq6IGh1H5g/viewform) .