**Job Title:** Principal Scientist, Ocular In Vivo Translational Sciences **Location:** Cambridge, MA **About the Job** Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. We are seeking a highly skilled Principal Scientist with expertise in in vivo ocular research to join Sanofi's innovative Ophthalmology Research team. You will lead IND-enabling preclinical studies, spearhead the development of novel disease models, and drive the advancement of innovative therapies for vision-threatening diseases. In this role, you will combine therapeutic strategy with hands-on expertise to influence drug development strategies throughout the ophthalmology portfolio while leading translational projects. **Main Responsibilities** + Lead, design, execute, and analyze in vivo ocular studies, including IND-enabling studies, in relevant animal models to support drug discovery and development programs + Assess pharmacokinetics, pharmacodynamics, efficacy, and safety of potential ocular therapeutics, utilizing advanced imaging modalities (OCT, fundus photography, ERG, IOP, OKR) in small and large animals + Develop and characterize preclinical ocular disease models, both internally and through external partnerships, to support therapeutic efficacy evaluation + Perform and oversee a wide range of ocular dosing procedures and sophisticated histological techniques, including various administration routes in rodents + Conduct and supervise molecular analyses (digital PCR, ELISA, Western blotting) and operate automated platforms for molecular and histological assays + Manage ongoing studies, write pre-clinical regulatory documents for IND submission, and lead the development of regulatory documentation + Author scientific publications, present research findings at internal governance meetings and external conferences, and provide scientific expertise on ocular drug development strategies + Collaborate closely with internal project teams and external partners to advance ophthalmology research programs and establish/maintain external collaborations + Provide scientific leadership in translational project teams and drive strategic decisions in drug development + Ensure project flexibility and timely delivery by adapting to changing needs and managing resources effectively **About You** + Earned PhD in Vision Science, Ophthalmology, Pharmacology, Molecular Biology, or related field with 5+ years of relevant post-PhD/doc experience in an academic or pharmaceutical setting + Expertise in designing and executing translational research studies + Strong track record in leading in vivo ocular translational studies + Proven leadership and mentoring abilities + Experience with various therapeutic modalities (small molecules, biologics, gene therapies) + Strong publication record in peer-reviewed ocular journals + Experience in translational research and clinical applications + Proficiency in managing external collaborations and CRO relationships + Strategic project planning and execution skills **Preferred qualifications** + Direct experience developing and characterizing ocular disease models using molecular and histological methods + Direct experience designing and executing NHP studies with CROs and performing analyses + Direct experience conducting in vivo PK, PD and efficacy studies + Experience in regulatory documentation preparation + Demonstrated ability to lead cross-functional teams + Experience analyzing data using computational approaches **Skills and competencies** + Advanced technical mastery with ability to be hands-on, provide guidance, troubleshoot complex problems, and train others in in vivo techniques and readouts + Program management skills to lead complex research initiatives and cross-functional teams + Ability to drive key decisions and collaborate with stakeholders across the organization **Why Sanofi?** At Sanofi, we are united by a shared purpose: to help people live healthier lives. Our research is driven by a passion for science and innovation. As part of our ophthalmology research team, you will have the opportunity to shape the future of vision care and make a meaningful impact on the lives of patients worldwide. If you are a strategic leader with a passion for advancing ophthalmology research, we invite you to join us in our mission to bring transformative therapies to the world. **Why Choose Us** + Bring the miracles of science to life alongside a supportive, future-focused team. + Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. + Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. + Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. \#GD-SA \#LI-SA \#LI-Onsite \#vhd **Pursue** **_progress_** **, discover** **_extraordinary_** Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) ! _US and Puerto Rico Residents Only_ Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally inclusive and diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; natural or protective hairstyles; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. _North America Applicants Only_ The salary range for this position is: $122,250.00 - $176,583.33 All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through the LINK (https://benefits.sanofiusallwell.com/fleet/public/index/ba511bf8-5c32-4828-9861-ab985fffab90/?cid=sanofi) . Global Terms & Conditions and Data Privacy Statement (https://www.sanofi.com/en/careers/global-terms-and-conditions/) Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visiting www.sanofi.com or via our movie We are Sanofi (https://youtu.be/96EwNjb1TLo) As an organization, we change the practice of medicine; reinvent the way we work; and enable people to be their best versions in career and life. We are constantly moving and growing, making sure our people grow with us. Our working environment helps us build a dynamic and inclusive workplace operating on trust and respect and allows employees to live the life they want to live. All in for Diversity, Equity and Inclusion at Sanofi - YouTube (http://www.youtube.com/watch?v=SkpDBZ-CJKw&t=2s)