_Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l’international, l'anglais étant la langue de travail._ _This job offer is accessible to all, regardless of gender._ **Job title** **:** _Pharmacometrician - Principal Scientist in Drug Disease Modeling_ + _Location: Gentilly_ **_About the job_** The Disease Modeling department at Sanofi is seeking a highly talented and motivated **Pharmacometrician** to join our dynamic team and contribute to the advancement of Sanofi R&D portfolio. This group is part of the Quantitative Pharmacology within Translation Medicine Unit at Sanofi R&D. At Sanofi, a global health care and pharmaceutical company, modeling and simulation plays an increasingly important role and support critical decision making throughout various phases of drug research & development. Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress. Join our Drug Disease Modeling (DDM) team as a Pharmacometrician, where you will support Sanofi’s R&D portfolio with innovative modeling strategies and drive the development and application of cutting-edge DDM methodologies. **Main responsibilities:** + Function as part of a team to develop and implement multiscale computational drug disease models in different therapeutic areas (oncology, neurology, immunology and inflammation) + Implement innovative quantitative methods to integrate data of pharmacokinetics, biomarkers, and clinical outcome with data of patient characteristics and knowledge of disease mechanisms and disease states to facilitate quantitative decision making + Prepare DDM modeling and simulation strategies to support research and development programs + Conduct hands-on data analysis and simulation, interpretation of results and reporting in compliance with Good Clinical Practice (GCP) and guidance of regulatory authorities + Collaborate cross-functionally with clinical pharmacology, biostatistics, translational medicine, and therapeutic area teams. + Communicate modeling and simulation results to both technical and non-technical stakeholders + Maintain drug disease modeling expertise through comprehensive education including attendance and participation in conferences, scientific workshops etc. **_About you_** + **Experience** : 3+ years of experience on modeling and simulation in the pharmaceutical industry, CRO health-related consulting company, academic experience (experience within pharmaceutical industry is highly desired) + **Soft and technical skills** + broad-based knowledge of quantitative clinical pharmacology related areas such as PK/PD, statistics and systems pharmacology required + proficiency in programming languages (e.g. R, Matlab, Python) and solid hand-on experiences within a variety of computational modeling tools such as Monolix, Nonmem and Julia + strong oral and written communication skills as well as desire to work within an interdisciplinary team environment + experience in joint modeling/machine learning/deep learning is a plus + **Education** : PhD in pharmacometrics, biostatistics, applied mathematics or related field + **Languages** : Fluent spoken and written English is required and working knowledge of French is a plus **Pursue** **_Progress_** **.** **Discover** **_Extraordinary_** **.** Progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. You can be one of those people. Chasing change, embracing new ideas and exploring all the opportunities we have to offer. Let’s pursue progress. And let’s discover extraordinary together. At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity. Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) ! **\#LI-FRA** **\#LI-Hybrid** **Pursue** **_progress_** **, discover** **_extraordinary_** Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) ! Global Terms & Conditions and Data Privacy Statement (https://www.sanofi.com/en/careers/global-terms-and-conditions/) Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visiting www.sanofi.com or via our movie We are Sanofi (https://youtu.be/96EwNjb1TLo) As an organization, we change the practice of medicine; reinvent the way we work; and enable people to be their best versions in career and life. We are constantly moving and growing, making sure our people grow with us. Our working environment helps us build a dynamic and inclusive workplace operating on trust and respect and allows employees to live the life they want to live. All in for Diversity, Equity and Inclusion at Sanofi - YouTube (http://www.youtube.com/watch?v=SkpDBZ-CJKw&t=2s)