**At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives.** We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting-edge molecular science and AI, we ask ourselves every day: _“What would I do if this patient were my mom?”_ That question drives everything we do. But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose. **Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.** **Position Summary** Caris Life Sciences is seeking a creative, driven, and technically strong Data Scientist – Deep learning to join our Computational Pathology team. This role focuses on developing large-scale, generalizable machine learning models that learn rich representations from complex, high-dimensional data to support translational research and biomarker discovery. The successful candidate will play a central role in shaping Caris’ next-generation AI capabilities by designing scalable training pipelines, advancing representation learning approaches, and collaborating closely with scientific and clinical experts. This position is ideal for individuals with a strong background in deep learning, transformer-based architectures, and computational pathology, who are excited about building foundation-level modeling frameworks rather than task-specific solutions. **Job Responsibilities** + Design, train, and evaluate foundation-style machine learning models that learn robust and reusable representations from large-scale datasets. + Develop and maintain scalable model training infrastructure using PyTorch and distributed training paradigms (e.g., multi-GPU and multi-node setups). + Train and adapt transformer-based architectures for representation learning across diverse data sources. + Apply self-supervised, weakly supervised, and representation learning techniques to leverage partially labeled or unlabeled data. + Build flexible modeling frameworks capable of integrating multiple data sources and heterogeneous signals. + Collaborate with pathologists, scientists, and engineers to ensure models are biologically meaningful and aligned with translational research goals. + Process, curate, and analyze large, complex datasets using efficient and reproducible workflows. + Support exploratory analyses, downstream modeling, and internal research initiatives using learned representations. + Contribute to internal technical documentation, research outputs, and long-term modeling strategy. + Follow best practices in software engineering, experiment tracking, and collaborative model development. **Required Qualifications** + PhD in Computer Science, Data Science, Computational Biology, Bioinformatics, Engineering, Mathematics, or a related quantitative field with exposure to biological or medical data. + 0–4 years of experience applying machine learning or deep learning in research or industry settings (postdoctoral experience acceptable). + Strong understanding of deep learning model training, optimization, and evaluation. + Hands-on experience with transformer-based models, including both language-focused and vision-focused architectures. + Proficiency in Python and PyTorch. + Hands-on experience with distributed training (e.g., PyTorch DDP, multi-GPU or multi-node workflows). + Experience working in Linux environments and using Git for version control. + Ability to work with large datasets and complex data pipelines. + Strong written and verbal communication skills. **Preferred Qualifications** + Background in computational pathology or experience working with large-scale imaging data. + Experience training large representation models or foundation models. + Familiarity with self-supervised and representation learning techniques, such as contrastive learning, DINO-style approaches, or related methods. + Experience working with multiple data sources in unified modeling frameworks. + Experience with cloud-based machine learning environments, including distributed training workflows (e.g., AWS, SageMaker). + Strong engineering mindset with attention to reproducibility, scalability, and model robustness. + Background in biomedical, translational, or applied research environments. **Physical Demands** + This position requires extended periods of computer-based work, along with collaboration with subject matter experts and business partners in person or via remote conferencing. **Training** + All job-specific, safety, and compliance training will be provided based on the responsibilities of the role. **Other** + Periodic travel and work during evenings, weekends, or holidays may be required. **Conditions of Employment:** Individual must successfully complete pre-employment process, which includes criminal background check, drug screening, credit check ( applicable for certain positions) and reference verification. This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time. Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability. Caris Life Sciences is a leading innovator in molecular science and artificial intelligence focused on fulfilling the promise of precision medicine through quality and innovation. Caris is committed to quality and excellence at our state-of-the-art laboratories. Learn more about our tissue lab and the advanced technologies that are helping improve the lives of cancer patients.