Singapore, SGP
58 days ago
Bioinformatics Scientist, Assay Design and Pipelines
**Work Schedule** Standard (Mon-Fri) **Environmental Conditions** Office **Job Description** **Position Summary** We are seeking a skilled and motivated Bioinformatics Scientist to join our team, specializing in assay and content development for qPCR, dPCR, and CE technologies. The role focuses on delivering high-quality assays on schedule and contributing to the development and maintenance of computational pipelines, databases, and infrastructure to scale assay development. This position requires strong domain knowledge of genomics, PCR-based methods, and proficiency in bioinformatics pipeline development. You will convert biological questions into assay strategies and assign robust primer/probe sets. You will streamline workflows and optimize code for efficiency and scalability. Collaboration with other bioinformatics scientists, product management, and customer support colleagues is essential. **Primary Responsibilities** + Design, develop, and optimize qPCR assays for various applications, including gene expression, genotyping, copy number analysis, and pathogen detection. + Analyze and interpret complex genomic and sequence data to support target selection and assay development. + Develop, maintain, and optimize bioinformatics pipelines and workflow automation for large-scale assay development. + Maintain version-controlled repositories, documentation, and reproducibility across computational workflows. + Participate in the publication or productization of developed algorithms, pipelines, or tools + Prepare and present scientific reports and presentations to communicate findings and progress. **Required Qualifications** + Degree or Masters degree in bioinformatics, Computational Biology, Molecular Biology, Bioinformatics, or related fields. Preferred with 2+ years of relevant experience. + Strong genomics & molecular biology domain knowledge in at least one of the domains in plants, mammalian, microbial, and oncology systems. + Bioinformatics stack: IGV, BLAST, BWA/other aligners; major databases (GenBank, Ensembl); experience across genomics, and quantitative data with strong analytical, problem-solving skills. + Strong programming for scripting: **Advanced Python** + Teaming & execution: excellent communication; effective cross-functional collaboration; able to work independently and manage multiple projects concurrently. **Preferred Qualifications** + Familiar in R, additional solid debugging. experience in C/C++/Java/Perl/Python/JavaScript/ReactJS; + Familiarity with workflow orchestration frameworks (Nextflow, Snakemake, Latch) or cloud computing and high-performance computing environments. + Fundamental understanding of assay development, PCR chemistry + Familiarity with cancer biology, genetics + Experience with other assay development platforms, such as NGS, microarrays, etc. + Hands-on experience with qPCR/dPCR instrumentation, assay optimization and validation. Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.
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