We seek an experienced scientist to advance our research at the University of California, Los Angeles Department of Neurology in the laboratory of Dr. Rexach.
Dr. Rexach’s laboratory studies Alzheimer’s and related dementias. Our research focuses on genetic mechanisms of disease as well as interventions with primary focus on neuroimmune mechanisms and resilience factors contributing to neurodegeneration. We conduct studies in iPSC-derived stem cell models that allow us to model disease and disease modifying factors. The successful candidate will be responsible for supervising graduate students, post-doctoral fellows, and undergraduate student researchers, preparing manuscripts for publication in scientific journals, and assisting with the preparation of grant proposals.
Specific Responsibilities
Responsibilities of this position include study design, data acquisition, statistical computation, and literature review and manuscript/grant preparation. This includes ability to work with the PI to develop and utilize a host of iPSC models if dementia, and work closely with senior faculty and the PI supervising teams of technicians and students to complete the multidisciplinary tasks involved in each study (iPSC culturing, quality controls, single cell sequencing, phenotyping, genetic and pharmacological manipulation, functional readouts including electrophysiology). The assistant researcher should also have experience with neuron and/or glial cell culture in to study neurotoxicity, aggregation or inflammatory responses . The scientist is expected to submit at least one career training grant by the end of the first year and assist in grant preparation as a co-investigator by the end of the first year.
Qualifications
Applicants must have a PhD and postdoctoral fellowship. Ideal candidates will have a strong background in the following areas: protein aggregation pathologies, different types of dementia (tau, Alzheimer’s, mixed), iPSC models, genetic manipulation, and data analysis.
Applicants must have experience with the use of flow cytometry, immunohistochemical, iPSC culturing, gene induction and knockdown with CRISPR and viral vectors and statistics. Prior experience with preclinical models of neurodegeneration is preferred.
Additional Duties
• Ability to work on multiple projects efficiently and effectively.• Ability to work independently on scientific projects• Required to communicate well with other scientists.• Candidate should have 5 years research experience in neuroscience in an academic setting or equivalent. • The candidate will report directly to the Principal Investigator and will successfully carry out experiments and analyze the data generated with minimal supervision.
Application Procedure:
Application procedure: Apply by submitting your application to our online RECRUIT system at https://recruit.apo.ucla.edu/JPF10779 . Screening of applicants will begin immediately and will continue until the position is filled.

Document requirements
Curriculum Vitae - Your most recently updated C.V.
Cover Letter (Optional)
Statement of Research (Optional)
Reference check authorization release form - Complete and upload the reference check authorization release form

The posted UC salary scales set the minimum pay determined by rank and step at appointment. See
https://www.ucop.edu/academic-personnel-programs/_files/2025-26/represented-july-2025-scales/t13-b.pdf

The salary range for this position is $93,400-$110,400

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