At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Lilly’s Synthetic Molecule Design and Development (SMDD) is involved in key activities for the development of active pharmaceutical ingredients and formulated drug products from pre-clinical phases through commercialization of drug substances and drug products for small molecules, synthetic oligonucleotides, and synthetic peptides. Our scientists develop key technical and business solutions across the portfolio using their deep technical expertise to speed up testing of the clinical hypothesis and overall drug development. SMDD tackles this diversity of responsibilities by recognizing that an even greater diversity of talents and cultures is necessary to deliver the next generation of life changing medicines to patients.

Chemical Hazards Lab (CHL)
 The Chemical Hazards Lab (CHL) within the Process Design and Development division of Synthetic Molecule Design and Development (SMDD) at Eli Lilly and Company provides thermal and dust hazard analyses for products and processes using rigorous experimental design and execution in conjunction with established methods for assessing thermal stability. The majority of the CHLs activity is related to small molecule development assets, although consultation and services are also provided to other Lilly Divisions (e.g., Manufacturing, pilot-plants, kilo-labs, Biologics R&D, Discovery Chemistry, and External Manufacturing).

The CHL workflow includes internal experimental activities (calorimetry, SADT Determination, flash point determination, Fall hammer tests), oversight of outsourced thermal testing activities (Dust explosivity, Vent Sizing, UN explosivity), and collaborating with SMDD scientists to design, develop, and execute inherently safe processes with Lilly Manufacturing or in our third party supplier network.

Job Requirements
 Process Safety Design, Development, Testing and Consulting

Perform and/or oversee the design and implementation of reaction calorimetry, thermal stability, flammability, explosivity, and chemical compatibility tests.Interpret experimental data and provide specific guidance to scientists to eliminate or minimize/mitigate risks due to detected thermal hazards.Serve as a champion for good process safety practices through specific proactive guidance to development teams.Participate in root-cause experimentation and analysis to determine if incidents were caused by reactive chemical hazards.Coordinate outsourced thermal hazards testing for Lilly Development ProjectsPerform process safety literature reviewsEnsure creation of accurate test reports and timely delivery of results/interpretation for all thermal hazards testing.Author and/or Review Process Safety Reports containing process safety testing, compound test analysis and synthetic route safety analysis for projects reaching appropriate milestones or as requested; ensure timely delivery of reports to project teams, Lilly manufacturing, and third party organizations as appropriate.Review SURFs (Scale-Up Review Forms) prior to scale-up execution for the Discovery Chemistry Synthesis Group (DCSG) and SMDD as needed.Provide process safety training and consultation for Lilly employees and our network partners.Increase performance and capabilities of the labReview and assess process safety needs for new or additional test capabilitiesResearch and develop new technology for applicability to process developmentReview proposed synthetic routes and provide process safety input to aid in prioritization of route design efforts.Complete risk assessments for API synthetic route development at all stages (Route Design, Route Definition, Route Optimization) of developmentCollaborate with Development Teams to implement inherently safer chemical design changes or safety-mitigating process improvementsDocument experiments in electronic lab notebook.Author internal technical reports for broad-based safety topics.Maintain current working knowledge of process safety/dangerous good transportation laws as they relate to process safety, chemical reactivity and thermal stability.Employee Development and ManagementDevelop skills and internal contacts to become a trusted expert on chemical process safety, inherently safer chemical process design, and chemical reactivity matters within LillyAct as technical mentor for technical staff across Lilly functionsPublish safety related articles in applicable journalsAttend and present at process safety-related conferences.Develop and enhance Lillys process safety reputation by representing Lilly as contributing member or leader in local, national or global process safety professional organizations

Basic Qualifications
PhD in Chemistry or Chemical Engineering or related discipline

MS in Chemistry or Chemical Engineering or related discipline with minimum of 8+ years of experience in process safety and lab experimentation

BS in Chemistry or Chemical Engineering or related discipline with minimum of 12+ years of experience in process safety and lab experimentation
 

Additional Skills/Preferences

Experience in synthetic molecule drug substance process development and related safety assessments.Reaction Calorimeter, Differential Scanning Calorimeter, Accelerating Rate Calorimeter, Differential Accelerating Rate Calorimeter and micro calorimeters, HPLC, GC and Optimelt.Knowledge and experience for data interpretation and analysis of experimental results as applied to process safety assessments, including concepts of adiabatic temperature rise, adiabatic time to maximum rate, Stoessel reactivity classes, Semonov Diagrams and critical temperatures.Basic knowledge of dust explosivity (Kst and Pmax), vent sizing calculations, electrostatics and other tests/test methods applicable to commercial scale process safety analysis and shipping practices.Knowledge of industry best practices for process safety, process safety test analysis, and chemical reactivity analysis Experience with commercial manufacturing scale process design and processing equipment, including scale-up and troubleshooting.Experience with commercial scale process controls and basic knowledge of process control designExperience with inherently safer chemical process designKnowledge of chemical reactivity and industrial chemical reactivity accidentsKnowledge of Organic Chemistry and/or Chemical Engineering fundamentals, including reaction mechanisms, kinetics, and thermodynamics.Understanding and implementation of first principles modeling and use of modeling tools such as DynoChem, Aspen Properties, gPROMS Process Builder, CHETAH and AKTS softwareKnowledge of modeling critical scale-up parameters to predict potential hazardous behavior on scale-upsKnowledge of model decomposition kinetics through application of Model-Free kinetics and other techniques as appropriate.theoretical calculations as necessary to estimate heat of decomposition, heat of reaction, flammability parameters, and other difficult to measure quantities.Oral and written communication skillsOrganizational and interpersonal skillsLeadership and team work skillsCoaching/mentoring skills

Additional Information:

Location: Indianapolis, IN LTC N

Travel: less than 10%

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$126,000 - $204,600

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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